It was concluded that some useful acts by using virginiamycin and black pepper extract on growth and health for broilers chicks. This improvement may be due to the biological functions to improve growth or that may be due to its role as stimulant, enhanced digestibility, anti-oxidant, anti-microbial, anti-fungal activities or maybe the prevention of gastric toxicity. Although the beneficial effects on health and growth are believed to be mediated by effects on gastrointestinal macrobiotic, the underlying mechanisms remain to be discovered. However further studies are needed to more detail explanation