Methods
Search Methods
Potential studies were identified by searching the PubMed
(1966 to July 1, 2011) and EMBASE (1974 to July 1, 2011)
databases for “migraine prophylaxis” combined with the terms
“adherence” OR “compliance” and “migraine prophylaxis”
combined with each of the following medications: “propranolol”
OR “amitriptyline” OR “topiramate” (Figure 1). The
medications chosen for this review are the 3 most commonly
used oral medications for migraine prophylaxis, and each is