Patton Oswalt as Remy. Director Brad Bird chose Oswalt after hearing his food-related comedy routine.[3]
Lou Romano as Alfredo Linguini, the son of Auguste Gusteau and Renata Linguini.
Janeane Garofalo as Colette Tatou, Gusteau's rôtisseur, inspired by French chef Hélène Darroze.[4][5]
Ian Holm as Skinner, a diminutive chef and owner of Auguste Gusteau's restaurant. Since Gusteau's death, Skinner has used the Gusteau name to market a line of cheap microwaveable meals. Skinner's behavior, diminutive size, and body language are loosely based on Louis de Funès.[6]
Brian Dennehy as Django, Remy and Emile's father and the leader of the rats.
Peter O'Toole as Anton Ego, a restaurant critic. His appearance was modeled after Louis Jouvet.[7]
Brad Garrett as Auguste Gusteau (whose first and last names are anagrams of each other). Many reviewers believe that Gusteau is inspired by real-life chef Bernard Loiseau, who committed suicide after media speculation that his flagship restaurant, La Côte d'Or, was going to be downgraded from three Michelin stars to two.[8] La Côte d'Or was one of the restaurants visited by Brad Bird and others in France.[9]
Peter Sohn as Emile, Remy's older brother.