Background: Safflower regeneration through tissue culture has long been limited to low frequency and lack of an efficient
protocol that suitable for most safflower cultivars. In past decades, researches had been carried out to investigate safflower
regeneration through tissue culture and great progress had been made. Objective: To investigate factors that affect safflower
regeneration through tissue culture principally. Methods: This article summarized available literatures about advancements in
safflower regeneration, especially discussed factors affecting safflower tissue culture in detail. Results: Safflower regeneration
was fairly hard than other congeneric plants, such as chrysanthemum. The genotype, seedling age, type of explants, medium
components, plant growth regulators and other additives all had specific influences on safflower tissue culture. More deepgoing
researches need to be undertaken to establish an effective safflower regeneration system