Recommended therapy for type 1 diabetes consists of the following:
1. Use MDI injections (three to four injections per day of basal and prandial insulin)
or CSII therapy.
2. Match prandial insulin to carbohydrate intake, premeal blood glucose, and anticipated
physical activity.
3. For most patients (especially those at an elevated risk of hypoglycemia), use
insulin analogs.
4. For patients with frequent nocturnal hypoglycemia and/or hypoglycemia unawareness,
a sensor-augmented low glucose threshold suspend pump may be considered.
Pramlintide
Pramlintide, an amylin analog, is an agent that delays gastric emptying, blunts
pancreatic secretion of glucagon, and enhances satiety. It is a U.S. Food and Drug