In the intestine, bile plays an important role in emulsify lipids, which enables intramural hydrolysis and absorption of lipids nutrient and have a detergent-like function.Since the cell membranes of microorganism are composed of lipids and fatty acids, the bile salts are critical to them. However,
some microorganisms are able to reduce this detergent effect by their ability of hydrolyzed bile salts by BSH and thus to decrease their solubility.