Tributyltin (TBT) is a ubiquitous c

Tributyltin (TBT) is a ubiquitous contaminant in aquatic environment, but the detailed mechanisms underlying the toxicity of TBT have not been fully understood. In this study, the effects of TBT on behavior,energy metabolism and endoplasmic reticulum (ER) stress were investigated by using Chinese rare minnow larvae. Fish larvae were exposed at sublethal concentrations of TBT (100, 400 and 800 ng/L) for 7 days. Compared with the control, energy metabolic parameters (RNA/DNA ratio, Na+-K+-ATPase) were significantly inhibited in fish exposed at highest concentration (800 ng/L), as well as abnormal behaviors observed. Moreover, we found that the PERK (PKR-like ER kinase)–eIF2a (eukaryotic translation initiation factor 2a) pathway, as the main branch was activated by TBT exposure in fish larvae. In short, TBT-induced physiological, biochemical and molecular responses in fish larvae were reflected in parameters measured in this study, which suggest that these biomarkers could be used as potential indicators for monitoring organotin compounds present in aquatic environment.

ผลลัพธ์ (ไทย) 1:

Tributyltin (TBT) is a widespread contaminant in the water environment. However, detailed mechanisms underlying the toxicity of TBT is not fully understood in this study, the effects of TBT in behavior. Metabolism and stress endoplasmic alums (ER) was investigated using embryonic fish, rare Chinese larvae of fish were exposed to concentrations sublethal of TBT (100, 400 and 800 ng / L) 7 days compared to the parameters. metabolic control (RNA / DNA ratio Na + -K + -ATPase) are banned in fish exposed to a high concentration (800 ng / L), and abnormal behavior was observed also we found. that perk (PKR like ER kinase) - corridor eIF2a (eukaryotic translation start multiplying 2a) is the main branch run by TBT in fish larvae in the short TBT was physiological, biochemical and molecular responses in fish larvae is reflected in the parameter. measured in this study, which suggests that these biomarkers can be used as an indicator for monitoring possible organotin compounds in the aquatic environment.

ผลลัพธ์ (ไทย) 2:

Tributyltin (TBT) is a prevalent contaminants in the aquatic environment. However, the mechanisms underlying details of the toxicity of TBT has not been fully understood in this study, the effects of TBT on the behavior of metabolic and reticulum endoplasmic (ER) stress was investigated using embryonic necklace rare Chinese. Fish larvae are exposed to concentrations of sublethal TBT (100, 400 and 800 ng / L) for 7 days compared with the control parameters of energy metabolism (RNA / DNA ratio of Na + -K + -ATPase. ) was inhibited significantly in fish exposed to the highest concentration (800 ng / L), as well as behavioral disorders, noting also that perk (PKR kinase-like ER) -. eIF2a (to begin translating eukaryotic factor 2a) tract is the main branch is activated by exposure to TBT in fish larvae in the short-term physiological TBT-induced response in biochemistry and molecular biology in the fish ages. Light is reflected in the parameters measured in this study, which suggests that these biomarkers can be used as indicators of potential for monitoring organic tin compounds in the aquatic environment.