There has been a rapidly growing interest in Paenibacillus spp. since many were shown to be important for agriculture and horticulture (e.g. P. polymyxa), industrial (e.g. P. amylolyticus), and medical applications (e.g. P. peoriate). These bacteria produce various extracellular enzymes such as polysaccharide-degrading enzymes and proteases, which can catalyze a wide variety of synthetic reactions in fields ranging from cosmetics to biofuel production. Various Paenibacillus spp. also produce antimicrobial substances that affect a wide spectrum of micro-organismssuch as fungi, soil bacteria, plant pathogenic bacteria and even important anaerobic pathogens as Clostridium botulinum