The objective of this review is to discuss the ultrasound-assisted extraction (UAE) of various compounds
using clean, green solvents. We also outline fundamental mechanisms and factors associated with
the design and the development of clean, green UAE systems. Growing consumer demands for greener
alternatives and natural ingredients that do not involve toxic chemicals and the environmental and health
risk associated with the use of chemical solvents have attracted the interest of industries to sustainable,
non-toxic routes of extraction. UAE can benefit the chemical industry in multiple ways:
• enhancing extraction yield;
• enhancing aqueous extraction processes without using solvents;
• providing the opportunity to use alternative clean and/or green solvents by improving their extraction
performance; and,
• enhancing extraction of heat-sensitive components under conditions that would otherwise have low
or unacceptable yields.