Crustaceans utilize hemocyanin as the oxygen-carrying pigment .This copper-containing pigment has analogous role to hemoglobin in red-blooded animals. In addition to the physiological functions of copper, high levels of environmental copper have been found to be toxic to a variety of aquatic species. Copper concentration far exceeds the background of copper level of water (0.5 μgL-1). Due to toxic effects of dissolved copper, shrimp hatcheries routinely use water that treated with ethylenediaminetetraacetic acid to chelate free copper. In decapod crustaceans, 3 types of circulating hemocytes are recognized: hyaline, semi-granular and large granular cells [1]. They are involved in cellular immune responses that include phagocytosis and constitute the primary method of eliminating microorganisms or foreign particles [2]. In addition to phagocytosis, hemocytes are involved in coagulation and in the production of melanin via the prophenoloxidase system [3, 4]. Several physico-chemical parameters and environmental contaminants have been reported to affect the immune response in crustaceans and these have been reviewed by [5]. Copper (Cu2+) toxicity for fish is primarily related to structural damage to the gills [6]