For example, our group has observed that the C. elegans bre mutants with resistance to Cry5B are hypersensitive to Cry6A, and combination of Cry5B and Cry6A exhibits obvious synergism (Yu et al., 2014); Peng et al. (2011) have discov- ered that Cry6A shows distinct binding profile with the total protein of RKN than Cry5B.