Niacin is incorporated as nicotinamide adenine dinucleotides,
to form the prosthetic group of some enzymes,
involving in the electron transfer reactions of the respiratory
chain and oxidative phosphorylation. Nicotinic
acid protects against cardiovascular disease. Among
different treatments, there is an example of simvastatin–
niacin therapy used for cardiovascular protection in
patients with coronary disease and low plasma levels
of high-density lipoprotein (HDL) cholesterol (Brown,
Zhao, Chait, & Fisher, 2001). The authors have proved
that simvastatin plus niacin provides market clinical and
angiographically measurable benefits to patients with
coronary disease and low HDL levels.