The transcripts were analyzed to identify DEGs replying to cold stress in Arthrospira sp. TJSD091. After 24 h of growth transferred from the control temperature (35 ◦C) to cold stress conditions (15 ◦C), 1294 genes were differentially expressed, of which 645 were down-regulated genes and 649 were up-regulated genes (Fig. 3A and B). DEGs based on RPKM were plotted into clustered heat maps (Fig. 3C)