In summary, the journey for those suffering from dementia should include supportive strategies for assessment, problem identification, and nursing interventions that aim to promote their quality of life which hinges on the knowledge of the patients cognitive state. Most emphasis for hospitalized patients is on the presenting medical/surgical problem and interventions. Mental and behavioral health problems and interventions, associated with dementia care, are often overlooked or receive little priority. Furthermore, the difficulty in identifying features of the mental and behavioral health conditions make it imperative that nurses recognize the problems through a comprehensive assessment, then link nursing interventions to the problem. Using knowledge through best available evidence offers hope that complex patients with dementia can receive optimal care. This review provides an overview of practice recommendations that are thought to promote quality of care, therefore promoting quality of life. The work is a first step toward an integrated coordinated plan of care for patients with medical, surgical and mental and behavioral health conditions. Also, the work provides foundational content for use in the design and build of complex electronic clinical information systems. We recognize that the importance of the content and decision support to clinicians must also be recognized appropriately in adequate staffing, competencies, productivity, and payment systems to be fully implemented.