The combined production of biomass, hyaluronic acid (HA) and lactic acid (LA) in a glucose fed-batch
system was studied. The complex culture media used were formulated with commercial and residual
peptones from fish by-products. In all cases, fed-batch fermentations increased the productive period
of HA and LA. Tryptone led to the highest productions but with the peptones from shark by-products
similar LA concentrations and prominent HA levels were reached. Moreover, with this residual peptone
higher molecular weight of HA were achieved. On the other hand, the equations proposed adjusted with
accuracy and high statistical robustness the experimental kinetic profiles.