Although it has disappeared in many parts of the world, cholera is still a dangerous and deadly disease in some places on the planet, and luckily, limes and other citrus fruits can help defend against this often fatal condition. The lime juice, when added to potentially infected water, proved to be a very effective disinfectant, and even when it was consumed regularly after someone had been exposed to cholera-infected water, fatalities were reduced. Numerous studies were done on this application of lime juice, particularly following the horrible outbreak of cholera in Guinea-Bissau in 1994.