In different Staphylococcus aureus strains, there are
various toxin pools due to the reason that toxins are
encoded on MGEs which are variable in different
strains. These MGE-derived toxins have various types
including superantigens such as toxic shock syndrome
toxin (TSST), some leukotoxins such as PantonValentine
leukocidin which is typical factor in CAMRSA,
and exfoliative toxins. However, α-toxin,
β-toxin, some leukotoxins and phenol-soluble modulins
(PSMs) are synthesized in almost all strains. Different
expression levels of toxin genes lead to different
pathogenic activities. For example, obvious pathogenic
differences are observed between Agr-positive strains
and Agr-negative ones, and Agr is able to manage many
toxin genes (66).
In different Staphylococcus aureus strains, there arevarious toxin pools due to the reason that toxins are encoded on MGEs which are variable in differentstrains. These MGE-derived toxins have various typesincluding superantigens such as toxic shock syndrometoxin (TSST), some leukotoxins such as PantonValentineleukocidin which is typical factor in CAMRSA,and exfoliative toxins. However, α-toxin,β-toxin, some leukotoxins and phenol-soluble modulins(PSMs) are synthesized in almost all strains. Differentexpression levels of toxin genes lead to differentpathogenic activities. For example, obvious pathogenicdifferences are observed between Agr-positive strainsand Agr-negative ones, and Agr is able to manage manytoxin genes (66).
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