To better understand the relation between whole-grain consumption and weight gain related to nutrients found in whole grains, we adjusted for potential mediating nutrients, including food sources of fiber, magnesium, folate, and vitamins E and B-6. The association between changes in whole-grain intake and weight gain (0.75 and 1.24 kg weight gain for the highest and the lowest quintile category, respectively; P for trend < 0.0001) was mildly attenuated after adjustment for these nutrients (0.93 and 1.33 kg weight gain, respectively; P for trend < 0.01).