Recent research has linked inadequate vitamin D status to
non skeletal major chronic diseases, especially cardiovascular
diseases [8]. Existing data from laboratory studies, epidemiologic
and experimental research and prevention trials, suggest
that vitamin D reduces the risk of cardiovascular disease, and
a large, randomized, primary prevention trial, with adequate
dosing, combining cholecalciferol and omega-3 fatty acids,
is ongoing: the VITAL study. Poor vitamin D status was
associated with cardiovascular and overall mortality, despite
unconvincing results of vitamin D supplementation on mortality
[13]. Food-based strategies for enhancement of vitamin
D status in the population could lower cardiovascular risk if
a causal link between low vitamin status and cardiovascular
pathology would be demonstrated [14].
The aim of the present paper was to review the most
importantmechanisms explaining the possible association of
vitamin D deficiency and cardiovascular diseases, focusing
on recent experimental and clinical data.
Recent research has linked inadequate vitamin D status tonon skeletal major chronic diseases, especially cardiovasculardiseases [8]. Existing data from laboratory studies, epidemiologicand experimental research and prevention trials, suggestthat vitamin D reduces the risk of cardiovascular disease, anda large, randomized, primary prevention trial, with adequatedosing, combining cholecalciferol and omega-3 fatty acids,is ongoing: the VITAL study. Poor vitamin D status wasassociated with cardiovascular and overall mortality, despiteunconvincing results of vitamin D supplementation on mortality[13]. Food-based strategies for enhancement of vitaminD status in the population could lower cardiovascular risk ifa causal link between low vitamin status and cardiovascularpathology would be demonstrated [14].The aim of the present paper was to review the mostimportantmechanisms explaining the possible association ofvitamin D deficiency and cardiovascular diseases, focusingon recent experimental and clinical data.
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