Because the mycobacteria cell wall

Because the mycobacteria cell wall contains a large amount of
mycolic acid (lipophilic) (Palomino et al., 2002), the benzoic acid
derivative was tested. Despite its non-polar structure, did not
change in the MIC value against M. tuberculosis (Table 3). The
lipophilicity of compounds is an important feature to consider for
antimycobacterial activity of compounds, as reported by Castellar
et al. (2011) since this improves the penetration of substances into
the cell.