many population and animal studies using red yeast rice shows a consistent fall in cholesterol and triglyceride levels. in line with these studies, we expected a fall in lipid levels and oxidative stress in all the test groups when compared to the controls since all these groups were receiving red yeast rice. But we found that only the group fed with red yeast rice and rice bran oil combination showed lower lipid leveis, MDA levels and higher levels of beneficial paraoxonase enzyme in their serum when compared with the controls. The group on red yeast rice and coconut oil showed lower cholesterol and MDA levels and the group on red yeast rice and sunflower oil did not show any change in these parameters when compared with the controls. These findings indicate that the rice bran oil accentuated, whereas coconut oil and sunflower oil attenuated the beneficial effects of red yeast rice. Our study offers new insights about the effect of various edible oils on lipid lowering property of red yeast rice.