From this representation of the data, there is a wide range of ‘spontaneous’ cures when no primaquine is given. Although there is a fair amount of scatter of response at lower total doses, the upper asymptote of theEmaxmodel begins to plateau at the total dose associated
with 15 mg/day for 14 days. The scatter around that dose is still fairly wide, with tighter responses around the higher doses. The model also predicts that no dosing regimen overall consistently gives a complete cure, although the probability is greater with the higher
total doses tested. Although patient compliance may account for this phenomenon to some degree, pharmacogenetic polymorphisms may also account for this variability.