In primary cultured rat cortical cells treated with high levels of glutamate (sufficient to bring controls 100% viability to 0%), 5‐Hydroxy‐3,7,3′,4′‐tetramethoxyflavone was found to be protective in a concentration dependent manner from 0.1uM (13.4+/-0.5% survival) to 10uM (63.4+/-1.4% survival)