This chapter presents a review of the problems posed by unsuccessful organized crime prosecutions in the past. In recent years, a significant effort has been made, through legislation, law enforcement, and prosecution initiatives, to target organized crime operations more successfully. This effort has produced profound results. Prison sentences in organized crime cases now occur more often and are longer in duration than for virtually any other kind of crime. In the long term, however, the use of asset forfeiture may do more to destroy ongoing criminal enterprises than the incarceration of its current members. Innovative approaches to sentencing involving government monitoring and public education also show promise in making long-term contributions to the prevention of ongoing organized crime activity.