In our study, the levels of ALP were significantly
increased in the kidney of treated animals as shown in table
I and II. The mechanism of release of membrane bound
enzyme is less well understood. Alkaline phosphatase is a
membrane bound glycoprotein enzyme. Leibovitch et al.
(1991) observed increased levels of serum ALP in
pathological conditions involving the kidneys. The increase
in serum ALP might be derived from injury to the brush
border membrane of the renal tubular cells. Renal function
impairment might also be responsible for the increased serum
ALP. Nuyts et al. (1994) reported that human intestinal
alkaline phosphatase (hALP), a specific marker of proximal
tubular S3 segment, was elevated in the urine of
microalbuminuric diabetic patient.