A unique feature of these cross-linked HA gel matrices is the ability to form “nonequilibrium” or non-fully swollen gels,with a range of concentrations and rheological parameters that are effective delivery vehicles for different actives.
This property is a direct result of their structure and water-binding capacity. Non-equilibrium gels are typically better able to incorporate and entrap actives, as they may be further swollen in the presence of a solution of the active.
The actives therefore become part of the hydrated molecular cage of the cross-linked HA gel.