To understand whether direct solvent extraction yields higher levels of phenolics compared to serial solvent extraction, the triphala powder was extracted separately with the individual solvents—acetone, methanol, ethanol, and water. Similar to serial extraction, the methanol solvent extracted the highest level of phenolics (Figure 2(a)). Methanol extract also had the highest antioxidant potential and also showed greater antiproliferative activities compared to acetone, ethanol, and water extracts (Figure 2(b)). Thus, the methanol extract of triphala (MET) was used for further studies. Interestingly, although the ethanol and the water extracts had significantly higher total phenolics and antioxidant activity compared to acetone, the antiproliferative effects were not significantly higher.