Muscle ischemia also has been shown to produce
substantial metabolic stress, and potentially produces an
additive hypertrophic effect when combined with glycolytic
training (136,182). The stress-induced mechanisms theorized
to mediate the hypertophic response include alterations in
hormonal milieu, cell swelling, free-radical production, and
increased activity of growth-oriented transcription factors
(50,51,171). It also has been hypothesized that a greater acidic
environment promoted by glycolytic training may lead
to increased fiber degradation and greater stimulation of
sympathetic nerve activity, thereby mediating