It may be concluded that the streptozotocin through
its direct alkylating action can cause cellular necrosis and
selective destruction of the beta cells producing
hyperglycaemia at a dose of 45 mg/kg body weight. It may
also be stated that streptozotocin by producing diabetes
(hyperglycaemia) and hypoinsulinemia alters various
metabolic and enzymatic functions of kidney resulting in
various pathologic lesions. It may also be concluded that
the diabetic complications in kidney are associated with
alterations in enzyme levels.