) Histological changes in ankle joint of arthritic control animal. Section of joint cavity showing profound loss of articular cartilage and subchondral bone with ongoing loss of epiphyseal cartilage and bone tissue. (B) Histological changes in ankle joints of animal treated with MEBL 300 mg/kg BW, i.p. Section of joint cavity showing that loss of articular cartilage and subchondral bone with ongoing loss of epiphyseal cartilage and bone tissue was comparatively less than the arthritic control. (C) Histological changes in ankle joints of animal treated with MEBL 600 mg/kg BW, i.p. Section of joint cavity showing that loss of articular cartilage and subchondral bone with ongoing loss of epiphyseal cartilage and bone tissue was comparatively less than the animal treated with MEBL 300 mg/kg BW, i.p.