Insulin resistance and hyperinsulinemia have been strongly
associated with laminitis risk. It has therefore been
presumed, as yet without evidentiary support, that improvement
in insulin sensitivity and mitigation of hyperinsulinemia
will decrease the risk for laminitis in high-risk horses
and ponies. In many cases, the IR is related to obesity, and
a reduction in adiposity is needed for improvement in insulin
sensitivity. In both obese and nonobese high-risk animals,
longer term management of laminitis risk involves strict control
of NSC intake. A further consideration is the implementation
of a structured program of physical activity (exercise)
that can facilitate weight loss and improvement in insulin
sensitivity. Use of supplements (eg, magnesium, chromium
picolinate), touted to enhance weight loss and/or improve
insulin sensitivity, may also be considered.