The distribution of lipids among cellular compartments is tightly controlled.
The lipid compositions of
organelles vary dramatically. In addition, many organelles
have asymmetric distributions of lipid across the two
leaflets of their bilayers and lipids are often organized
into domains within membranes [2].
How cells sense and
regulate the complex mix and distribution of lipids in
organelles is, therefore, an important and challenging
question.
Answering this question requires knowledge
of how lipids are synthesized and degraded, how lipids
traffic between cellular compartments, and how these
processes are regulated.