Particle size is one of the most important parameters not only
for description of fundamental properties of materials, but also
within the biological systems as it can affect a number of key
features and processes, such as drug targeting, delivery or
distribution. Regarding nanosized particles, ISO standard ISO/TS
27687:2008 (ISO, 2008) provides their definition as an object with
a size between 1 and 100 nm. In the EU, the respective Commission
Recommendation (EC, 2011) defines a “nanomaterial” to be a
“natural, incidental or manufactured material containing particles,
in an unbound state or as an aggregate or as an agglomerate and
where, for 50% or more of the particles in the number size
distribution, one or more external dimensions is in the size range
1–100 nm”.
Particle size is one of the most important parameters not onlyfor description of fundamental properties of materials, but alsowithin the biological systems as it can affect a number of keyfeatures and processes, such as drug targeting, delivery ordistribution. Regarding nanosized particles, ISO standard ISO/TS27687:2008 (ISO, 2008) provides their definition as an object witha size between 1 and 100 nm. In the EU, the respective CommissionRecommendation (EC, 2011) defines a “nanomaterial” to be a“natural, incidental or manufactured material containing particles,in an unbound state or as an aggregate or as an agglomerate andwhere, for 50% or more of the particles in the number sizedistribution, one or more external dimensions is in the size range1–100 nm”.
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