Absolute
Aspirin allergy
Perioperative pain in setting of coronary artery bypass graft (CABG) surgery
Preterm infants with untreated proven or suspected infection; bleeding with active intracranial hemorrhage or GI bleed; thtombocytopenia, coagulation defects, proven or necrotizing enterocolitis, significant renal impairment, congenital heart disease where patency or the PDA is necessary for pulmonary or systemic blood flow