Some of this may be attributed to failure to take
in vivo activation or detoxification into account.
is also possible that the toxicity may not be solely related
to AChE inhibition (Mundy et al., 1978). A study on
the toxic effects of chlorpyrifos and parathion and their
oxon derivatives on foetal rat brain cell cultures suggested
that toxic effects and AChE inhibition are unrelated
(Monnet-Tschudi et al., 2000). Correlations
between in vivo toxicity and chemical properties of the
OP, without reference to underlying toxic mechanisms
have been better (Mundy et al., 1978; Mager, 1981).