The therapeutic efficacy of Tinospora cordifolia extensively used in Indian System of Medicine (ISM) has been established through modern testing and evaluation (pre-clinical and clinical trials) in different disease conditions. These studies place this indigenous drug a novel candidate for bioprospection and drug development for the treatment of such diseases as cancer, liver disorders, ulcers, diabetes, heart diseases and postmenopausal syndrome, etc. where satisfactory cure managements are still not available.