In OA treatment, the stopping of deterioration of disease is of prime importance, facilitation of patient’s gait and articular mobility by a decrease of pain, what influences quality of life. In the individual treatment plan, pharmacological and nonpharmacologic treatment are taken into consideration, for example, physiotherapy, mechanical aids, and surgical treatment. In current recommendations of American College of Rheumatology [5–7] concerning treatment of osteoarthritis, first of all, paracetamol is suggested, in monotherapy or in combination with, for example, codeine/tramadol in order to relieve pain and in coexisting inflammation, nonsteroidal anti-inflammatory drugs (NSAIDs) acting peripherally analgetically and anti-inflammatory. They are recommended for general and local use [8, 9]. Depending on a disease course, treatment may be extended by steroidal drugs (most commonly used locally), hialuronic acid, and local anestethics.