Study limitations
Specific cardiovascular biomarkers such as creatine kinase MB (CKMB) and troponin-i and troponin-t are better indicators for hypertension status. However we observed CPK and LDH level in our study. High-performance liquid chromatography (HPLC) is also a better method of quantifying of free MDA rather than TBARS methods that detected only MDA bound to TBA which was used in our study. Therefore, biomarkers that are more sensitive and specific may be used to confirm the hypertension and oxidative stress status in a future studies.
Conclusions
Kadukmy™ rich antioxidant supplementation causes significant reduction in the oxidative stress, increase NO level in the blood and reduction of serum total cholesterol that leads to reduction of endothelial dysfunction and attenuation of blood pressure in treated compared to untreated SHR. Thus, it contains potentially useful properties to be assessed for human use as treatment for hypertension.