Treatment of leukaemia, lymphoma, management of myelodysplasia Induction of remission: Adult & childn 100-200 mg/m2 or 2-6 mg/kg body wt by IV infusion over 24 hr or by IV inj for 5-7 days or until bone marrow hypoplasia occurs. Maintenance: 1-1.5 mg/kg IV/IM/SC once-twice wkly. Treatment of refractory disease Up to 3 g/m2 by continuous IV infusion every 12 hr for 6 days. Leukaemic meningitis 10-30 mg/m2 intrathecally every 2-4 days. To induce differentiation of malignant cells in patients w/ myelodysplastic syndromes 10 mg/m2 bid SC.