We introduced a COsensing
mechanism into the
bacteria E. coli by using the
CooA transcription activator
and pCooF promoter to
regulate expression of the
pchBA and BSMT proteins,
converting the endogenous
molecule chorismate into
methyl salic yl ate, the
wintergreen fragrance, in
t h e p r e s e n c e o f C O .