ฉันรักการแปล
To ascertain the neuroprotective effects of C and EC, it is necessary to understand the pharmacokinetic profiles in blood and brain, whether C and EC cross the blood-brain barrier (BBB). In vivo microdialysis is a technique for drug molecule sampling without depriving the subject of biological fluids and involving minimal disturbance of physiological functions. Moreove, the dialysis membrane is only permeable to small molecules,the analytes can be separated from enzymes by the dialysis membrane,and microdialysis samples need no further cleanup and will not undergo further metabolism after collection. For the pharmacokinetics study of drugs in brain, intracerebral microdialysis is the only technique offering the possibility to continuously monitor the local BBB transport of anbound drugs in tested animals,under physiological and pathological conditions. However,the drug concentration of brain dialysate is usually at a trace level ,and the collecting volume of dialysate sample is also limited . therefore,microdialysis combined with a high selectivity and high sensitivity analytical technique is the ultimate solution to the search for a brain real-time biosensor.