Plasma processes have certain advantages compared to the wet
chemical methods of surface modification. First of all, plasma processing
is an environment friendly energy-efficient technology because it does
not consume solvents. Secondly, it is a substrate-independent technology,
i.e. it can be applied to various materials including thermal
sensitive polymers. Finally, plasma modification does not affect
the bulk properties of materials unlike many wet chemical methods
requiring soaking in reactive mixtures, such as piranha solution or
KOH. Nevertheless, the deposition of plasma polymers exhibiting a
good layer stability combined with the sufficient concentration of
functional groups is still challenging [19]. Recently, we have
shown that stable amine-rich plasma films can be deposited
by plasma polymerization of non-toxic cyclopropylamine (CPA)
[20–22]. Although Lee et al. proposed that positively charged
amine surfaces enhance the adhesion of fibroblasts not all amine
plasma coatings can be applied for biomedical applications [6].
The release of toxic oligomers or a degradation of the plasma coating
may negatively affect the biocompatibility of the plasma coated
material [23]. The plasma polymers prepared from CPA have never
been tested before for their biocompatibility. The viability of cells
on these films has to be investigated because it is essential for the
optimization of these promising films aimed at the biomedical applications
and for a better understanding of amine surface–cell
interactions.
Plasma processes have certain advantages compared to the wetchemical methods of surface modification. First of all, plasma processingis an environment friendly energy-efficient technology because it doesnot consume solvents. Secondly, it is a substrate-independent technology,i.e. it can be applied to various materials including thermalsensitive polymers. Finally, plasma modification does not affectthe bulk properties of materials unlike many wet chemical methodsrequiring soaking in reactive mixtures, such as piranha solution orKOH. Nevertheless, the deposition of plasma polymers exhibiting agood layer stability combined with the sufficient concentration offunctional groups is still challenging [19]. Recently, we haveshown that stable amine-rich plasma films can be depositedby plasma polymerization of non-toxic cyclopropylamine (CPA)[20–22]. Although Lee et al. proposed that positively chargedamine surfaces enhance the adhesion of fibroblasts not all amineplasma coatings can be applied for biomedical applications [6].The release of toxic oligomers or a degradation of the plasma coatingmay negatively affect the biocompatibility of the plasma coatedmaterial [23]. The plasma polymers prepared from CPA have neverbeen tested before for their biocompatibility. The viability of cellson these films has to be investigated because it is essential for theoptimization of these promising films aimed at the biomedical applicationsและความเข้าใจของ amine ผิว – เซลล์โต้ตอบ
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