Relative to the 9–14-day-old nursing pigs tested in our study,
26–31-day-old weaned pigs had anatomically a more developed
cecum and colon. Although the related mechanisms were unclear,
gross and histologic lesions were limited to the small intestine of
PEDV-inoculated nursing and weaned pigs, but not the large
intestine. At PIDs 1–5, however, the large intestine of inoculated
nursing piglets was mostly accumulated with large amounts of
yellowish
fluid, which coincided with the high frequency of severe
watery diarrhea for the period. Large amounts of diarrheic
fluid
filled the small intestine of PEDV-inoculated weaned pigs at PID 5,
but stools in the large intestinal lumen appeared solid. By
pathological examinations, the structurally normal large intestine
of PEDV-infected weaned pigs may contribute to reabsorption of the large amount of water accumulated or released from the small
intestinal lumen, thereby maintaining hydration and leading to a
rapid recovery from disease in weaned pigs. The normal large
intestine of PEDV-inoculated weaned pigs also coincided with the
frequent lack of diarrhea (9/12 pigs tested) at PIDs 3 and 5.
Relative to the 9–14-day-old nursing pigs tested in our study,26–31-day-old weaned pigs had anatomically a more developedcecum and colon. Although the related mechanisms were unclear,gross and histologic lesions were limited to the small intestine ofPEDV-inoculated nursing and weaned pigs, but not the largeintestine. At PIDs 1–5, however, the large intestine of inoculatednursing piglets was mostly accumulated with large amounts ofyellowishfluid, which coincided with the high frequency of severewatery diarrhea for the period. Large amounts of diarrheicfluidfilled the small intestine of PEDV-inoculated weaned pigs at PID 5,but stools in the large intestinal lumen appeared solid. Bypathological examinations, the structurally normal large intestineof PEDV-infected weaned pigs may contribute to reabsorption of the large amount of water accumulated or released from the smallintestinal lumen, thereby maintaining hydration and leading to arapid recovery from disease in weaned pigs. The normal largeintestine of PEDV-inoculated weaned pigs also coincided with thefrequent lack of diarrhea (9/12 pigs tested) at PIDs 3 and 5.
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