After graduating (1963) from Wakefield High School,[3] Adams completed pre-med coursework at George Washington University. He began medical school without an undergraduate degree, and earned his Doctor of Medicine degree at Virginia Commonwealth University (Medical College of Virginia) in 1971. In the late 1960s one of his closest friends (a man, not a woman as depicted in the Patch Adams film) was murdered. Convinced of the powerful connection between environment and wellness, he believes the health of an individual cannot be separated from the health of the family, community, and the world. While working in an adolescent clinic at MCV, in his final year of med school, he met Linda Edquist, a fellow VCU student who volunteered in the clinic. Soon after graduation, Patch, Linda, and friends founded the Gesundheit! Institute (originally known to many as the Zanies), which ran as a free community hospital for 12 years.
Adams and Edquist married in 1975 and had two sons, Atomic Zagnut "Zag" Adams and Lars Zig Edquist Adams. The couple divorced in 1998.[