With regard to whether FiO2 should be increased before or after endotracheal suctioning, there was no consensus and not all of the studies reported this variable. In one study, the recommendation was to increase FiO2 30 to 60 seconds before suctioning and 1 minute thereafter.(6) Therefore, the suggestion of this review is that if the newborn’s SpO2 falls during endotracheal suctioning, hyperoxygenation at an FiO2 value 10 - 20% higher than that prior to suctioning should be performed during the next suctioning and 30 to 60 seconds before the procedure, and this fraction should be maintained during suctioning and 1 minute thereafter. However, SpO2 must be monitored in all newborns requiring endotracheal suctioning; therefore, individualized hyperoxygenation parameters should be adopted according to clinical alterations during the procedure.