1 Introduction
More than 30 million individuals worldwide are currently infected with human immunodeficiency virus type1 (Hiv-1), the cause of acquired immunodeficiency syndrome (AIDS), with 1.7 million deaths occurring from AIDS in 2011 (World Health organization, 2011) Currently, combination antiretroviral therapy is successful in controlling the disease progression of HIV infection. However antiretroviral therapy is known to be associated with deleterious complications such as metabolic derangement (Paula et al. 2013). Cessaion of antiretroviral therapy is not feasible as it may lead to viral rebound and disease progression (Costiniuk et al. 2013). Moreover, lifelong antiretroviral treatment poses a great economic burden to society as well as the family.
Alternative strategies to control HIV-1 infection are highly desirable. These may include manipulation of the immune response and other host factors. Prophylactic HIV-1 vaccines do not appear to show immediated promise,following of a recant clinical trail(Cohen,2007).
1 Introduction
More than 30 million individuals worldwide are currently infected with human immunodeficiency virus type1 (Hiv-1), the cause of acquired immunodeficiency syndrome (AIDS), with 1.7 million deaths occurring from AIDS in 2011 (World Health organization, 2011) Currently, combination antiretroviral therapy is successful in controlling the disease progression of HIV infection. However antiretroviral therapy is known to be associated with deleterious complications such as metabolic derangement (Paula et al. 2013). Cessaion of antiretroviral therapy is not feasible as it may lead to viral rebound and disease progression (Costiniuk et al. 2013). Moreover, lifelong antiretroviral treatment poses a great economic burden to society as well as the family.
Alternative strategies to control HIV-1 infection are highly desirable. These may include manipulation of the immune response and other host factors. Prophylactic HIV-1 vaccines do not appear to show immediated promise,following of a recant clinical trail(Cohen,2007).
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