The hypotensive effects of most antihypertensive drugs
are increased when administered with diuretics and other
antihypertensives. Many drugs can interact with the antihypertensive
drugs and decrease their effectiveness (eg,
antidepressants, monoamine oxidase inhibitors, antihistamines,
and sympathomimetic bronchodilators). When the
ACE inhibitors are administered with the NSAIDs, their
antihypertensive effect may be decreased. Absorption of
the ACE inhibitors may be decreased when administered
with the antacids. Administration of potassium-sparing
diuretics or potassium supplements concurrently with the
ACE inhibitors may cause hyperkalemia. When the
angiotensin II receptor agonists are administered with