The hexane and chloroform extracts of Derris scandens have displayed potent -glucosidase inhibitory and moderate free radical scavenging
activities. Phytochemical investigation of the active extracts led to the isolation of three new prenylated isoflavones, isoscandinone, scandenin A
and scandenin B in addition to scandenone, scandinone and 4, 5, 7-trihydroxybiprenylisoflavone as the main constituents, having -glucosidase
enzyme inhibitory and free radical scavenging properties. A reversed-phase HPLC method is developed to quantify these active principles in the
plant material, which can serve as an effective quality control method for standardization of D. scandens.
© 2007 Elsevier B.V. All rights reserved.
The hexane and chloroform extracts of Derris scandens have displayed potent -glucosidase inhibitory and moderate free radical scavengingactivities. Phytochemical investigation of the active extracts led to the isolation of three new prenylated isoflavones, isoscandinone, scandenin Aand scandenin B in addition to scandenone, scandinone and 4, 5, 7-trihydroxybiprenylisoflavone as the main constituents, having -glucosidaseenzyme inhibitory and free radical scavenging properties. A reversed-phase HPLC method is developed to quantify these active principles in theplant material, which can serve as an effective quality control method for standardization of D. scandens.© 2007 Elsevier B.V. All rights reserved.
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