This is a severe cutaneous adverse reaction seen with carbamazepine, phenytoin, phenobarbitone, primidone, zonisamide, lamotrigine and oxcarbazepine, occurring within the first 8 weeks of drug exposure.Initiation of lamotrigine treatment should comprise gradual dose escalation over several weeks in accordance with the product information. The safest approach is to discontinue antiepileptic medication if any rash develops within 8 weeks of commencement, and thence to avoid other causative AEDs.