Alzheimer’s disease (AD) is growing in impact on human health. With no known cure, AD is one of the
most expensive diseases in the world to treat. Huperzine A (HupA), a anti-AD drug candidate from the
traditional Chinese medicine Qian Ceng Ta (Huperzia serrata), has been shown to be a powerful and selective
inhibitor of acetylcholinesterase and has attracted widespread attention because of its unique pharmacological
activities and low toxicity. As a result, HupA is becoming an important lead compound for
drugs to treat AD. HupA is obtained naturally from very limited and slowly growing natural resources,
members of the Huperziaceae. Unfortunately, the content of HupA is very low in the raw plant material.
This has led to strong interest in developing sources of HupA. We have developed a method to propagate
in vitro tissues of Phlegmariurus squarrosus, a member of the Huperziaceae, that produce high levels of
HupA. The in vitro propagated tissues produce even higher levels of HupA than the natural plant, and
may represent an excellent source for HupA.
Alzheimer’s disease (AD) is growing in impact on human health. With no known cure, AD is one of themost expensive diseases in the world to treat. Huperzine A (HupA), a anti-AD drug candidate from thetraditional Chinese medicine Qian Ceng Ta (Huperzia serrata), has been shown to be a powerful and selectiveinhibitor of acetylcholinesterase and has attracted widespread attention because of its unique pharmacologicalactivities and low toxicity. As a result, HupA is becoming an important lead compound fordrugs to treat AD. HupA is obtained naturally from very limited and slowly growing natural resources,members of the Huperziaceae. Unfortunately, the content of HupA is very low in the raw plant material.This has led to strong interest in developing sources of HupA. We have developed a method to propagatein vitro tissues of Phlegmariurus squarrosus, a member of the Huperziaceae, that produce high levels ofHupA. The in vitro propagated tissues produce even higher levels of HupA than the natural plant, andmay represent an excellent source for HupA.
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